Unicity Feel Great System vs Isagenix: Which is Better?
By Fadi — Unicity Senior Director Distributor & Metabolic Coach · Published · Updated · 8 min read
Quick answer: Comparing Unicity Feel Great System vs Isagenix for weight loss, cleansing, cost, and long-term results. Which MLM health system actually delivers better...
The Company Backgrounds
Unicity International was founded in 2001 and focuses on metabolic health. It has 23+ years of clinical research and holds the distinction of having two products — Unimate and Unicity Balance — listed in the Prescribers' Digital Reference (PDR), the same reference used by US physicians. Both products are patented.
Isagenix was founded in 2002 and focuses on nutritional cleansing and meal replacement. Its products are widely distributed through an MLM structure. Isagenix holds no PDR listings for its core products.
How Each System Works
Isagenix 30-Day System
Isagenix combines:
- IsaLean shakes (meal replacements, ~240 cal each)
- Cleanse for Life (liquid supplement used on 2 "cleanse days" per week of 400–600 cal total)
- Snacks, accelerators, and optional add-ons
The mechanism is primarily caloric restriction, with "cleanse days" functioning as very low calorie fasting days.
Feel Great System
The Feel Great System uses:
- Unimate in the morning fasting window — appetite suppression, mental clarity, extended fast
- Unicity Balance before meals — glucose and insulin spike blunting
- 16:8 intermittent fasting — no meal replacement, no cleanse days
You eat real, unrestricted food during an 8-hour window. No shakes, no cleanse days, no special foods required.
Side-by-Side Comparison
| Factor | Feel Great System | Isagenix |
|---|---|---|
| Monthly cost | $169 (member price) | ~$300–450 USD |
| Mechanism | Insulin control + intermittent fasting | Calorie restriction + nutritional cleansing |
| Meal replacement? | No | Yes (1–2 shakes/day) |
| PDR listed? | Yes | No |
| Money-back guarantee | 90-day 100% | 30-day |
| Cleanse days required? | No | Yes (2 days/week) |
| Social eating compatible? | Yes | Moderate (shake dependency) |
The Cleanse Question
Isagenix's "cleanse days" are essentially very low calorie days (400–600 kcal) marketed as detoxification. Mainstream nutrition science does not support the concept of product-based detoxification — the liver and kidneys perform this function continuously. However, the caloric restriction on cleanse days does produce fat loss.
The Feel Great System achieves similar metabolic benefit through the 16-hour fasting window daily — a more sustainable and less disruptive approach than periodic extreme calorie restriction.
Cost: A Significant Difference
Isagenix's 30-day system with shakes, cleanse, and recommended supplements typically runs $300–450/month. The Feel Great System is$169/month at member pricing — roughly half to one-third the cost. Over a 90-day trial, that is a $400–900 difference.
Which Should You Choose?
For clinical credibility (PDR listings), cost (half the price), lifestyle flexibility (no shakes, no cleanse days), and guarantee length (90 vs 30 days) — the Feel Great System is the stronger choice.
Isagenix may suit those who prefer packaged shake convenience or have responded well to Isagenix in the past. But for a metabolically grounded, affordable, flexible protocol — the Feel Great System is hard to beat.
Order the Feel Great System with the 90-day guarantee →
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- Unicity vs Isagenix
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Order the Unicity Feel Great System
Ready to start? Order the Unicity Feel Great System at member pricing through this site, with personal coaching included. Questions about the business side? Learn more about becoming a Unicity distributor — Fadi, official Unicity Senior Director Distributor, is here to guide you.
Not sure where to start? Take our free 2-minute quiz — get a personalised Feel Great recommendation based on your health goals.
Scientific Synergy of Viscous Fiber and Fasting
The metabolic benefits of combining viscous soluble fiber (like the Biosphere Fiber matrix in Unicity Balance) with intermittent fasting are documented in clinical research. Soluble fiber slows gastric emptying and carbohydrate digestion, which stretches the satiety signal GLP-1 and keeps post-meal glucose spikes low. When you transition into the fasting window, your baseline insulin levels are already lower, allowing your body to transition into fat-burning mode (ketosis) much faster. This synergetic relationship is why combining Unimate yerba mate in the morning with Balance before lunch and dinner yields superior weight management and metabolic health outcomes compared to calorie restriction alone.
The Complex Science of Insulin Signaling and Resistance
Insulin is a hormone produced by beta cells in the pancreas, vital for regulating carbohydrates and fat metabolism. When glucose enters the blood, insulin binds to receptors on cellular membranes, initiating a cascade of intracellular signals that recruit glucose transporter proteins (GLUT4) to the cell surface. This allows glucose to enter cells, lowering blood sugar. However, chronic overconsumption of carbohydrates causes constant, high insulin release. Over time, receptors become desensitized to insulin, a condition known as insulin resistance. The pancreas compensates by producing even more insulin to force glucose into cells. This state of hyperinsulinemia prevents lipolysis (fat breakdown) and encourages lipogenesis (fat storage), particularly visceral fat accumulation around organs, leading to cardiovascular risk, metabolic syndrome, and fatigue.
The Physical Action of Soluble Fiber and Gastric Gel Barriers
Soluble fiber matrices, such as the Biosphere fiber system, operate on physical and chemical principles in the gut. Upon hydration in the stomach, the fiber particles swell and form a thick, viscous gel. This gel slows down gastric emptying, delaying the transit of food into the duodenum. In the small intestine, the viscous gel acts as a physical barrier, trapping sugars and starch molecules. This slows down their exposure to digestive enzymes (like amylase) and delays their absorption across the intestinal microvilli. Consequently, glucose enters the bloodstream gradually over several hours, rather than in a sudden spike. This flat glucose curve prevents the subsequent crash in blood sugar, eliminating reactive hypoglycemia, reducing insulin demand, and helping maintain stable, long-lasting energy.
The Metabolic Pathway of Autophagy and Ketosis
During a 16-hour fast, the body transitions from an anabolic state (storing energy) to a catabolic state (mobilizing energy). As liver glycogen stores are depleted, insulin levels drop, and glucagon levels rise. This shift activates hormone-sensitive lipase, which breaks down triglycerides in adipose tissue into free fatty acids. These fatty acids are transported to the liver, where they undergo beta-oxidation to produce ketone bodies (acetoacetate and beta-hydroxybutyrate). Ketones cross the blood-brain barrier, providing an alternative fuel source that is more energy-efficient than glucose and produces fewer reactive oxygen species. Fasting also triggers autophagy, where cells degrade damaged mitochondria, misfolded proteins, and viral components. This cellular recycling promotes longevity, reduces inflammation, and restores metabolic health.
Chlorogenic Acids and Theobromine in Concentrated Yerba Mate
Concentrated Yerba Mate extracts, such as Unimate, contain a high concentration of bioactive phytochemicals that support metabolism and mental clarity. Chlorogenic acids are polyphenol antioxidants that inhibit glucose-6-phosphatase, an enzyme involved in hepatic glucose production, thereby helping regulate blood sugar levels. Theobromine, a methylxanthine also found in cacao, acts as a mild central nervous system stimulant and smooth muscle relaxant. Unlike caffeine, which can cause vasoconstriction and jittery energy crashes, theobromine promotes vasodilation and a sustained, calm focus. Additionally, saponins in Yerba Mate have anti-inflammatory and cholesterol-lowering properties, supporting heart health and suppressing appetite during fasting windows.
Strategies for Achieving Metabolic Resilience and Flexibility
Metabolic flexibility is the body's capacity to adapt fuel oxidation to fuel availability, easily switching between burning carbohydrates and fats. In an unhealthy metabolic state, the body is locked into burning glucose, leading to frequent hunger and fatigue. To rebuild this flexibility, one must combine consistent fasting windows with targeted fiber supplementation. Taking a fiber matrix before meals slows digestion and insulin release, while morning fasting extends the fat-burning state. Regular physical activity, adequate sleep, and reducing refined sugar intake complement this protocol. Over weeks and months, cellular pathways adapt, insulin sensitivity improves, and energy levels stabilize, providing lasting resilience against modern chronic metabolic conditions.
The Complex Science of Insulin Signaling and Resistance
Insulin is a hormone produced by beta cells in the pancreas, vital for regulating carbohydrates and fat metabolism. When glucose enters the blood, insulin binds to receptors on cellular membranes, initiating a cascade of intracellular signals that recruit glucose transporter proteins (GLUT4) to the cell surface. This allows glucose to enter cells, lowering blood sugar. However, chronic overconsumption of carbohydrates causes constant, high insulin release. Over time, receptors become desensitized to insulin, a condition known as insulin resistance. The pancreas compensates by producing even more insulin to force glucose into cells. This state of hyperinsulinemia prevents lipolysis (fat breakdown) and encourages lipogenesis (fat storage), particularly visceral fat accumulation around organs, leading to cardiovascular risk, metabolic syndrome, and fatigue.
The Physical Action of Soluble Fiber and Gastric Gel Barriers
Soluble fiber matrices, such as the Biosphere fiber system, operate on physical and chemical principles in the gut. Upon hydration in the stomach, the fiber particles swell and form a thick, viscous gel. This gel slows down gastric emptying, delaying the transit of food into the duodenum. In the small intestine, the viscous gel acts as a physical barrier, trapping sugars and starch molecules. This slows down their exposure to digestive enzymes (like amylase) and delays their absorption across the intestinal microvilli. Consequently, glucose enters the bloodstream gradually over several hours, rather than in a sudden spike. This flat glucose curve prevents the subsequent crash in blood sugar, eliminating reactive hypoglycemia, reducing insulin demand, and helping maintain stable, long-lasting energy.
Step by step
- Morning Fasting: Start your day with Unimate to support GLP-1, boost energy, and extend your fat-burning window.
- Pre-Meal Balance: Take Unicity Balance 5-10 minutes before your first meal to reduce glucose spikes.
- Healthy Eating Window: Enjoy your first meal and keep a consistent eating window (typically 8 hours).
- Second Meal: Take Unicity Balance again before your second meal to close out your eating window.
Frequently Asked Questions
What is the Unicity Feel Great System?
The Unicity Feel Great System is a metabolic health protocol combining Unimate (yerba mate concentrate) and Unicity Balance (fiber matrix) with the 16:8 intermittent fasting schedule.
How does Unicity Balance support blood sugar?
Unicity Balance contains the Biosphere Fiber matrix which forms a viscous gel in your digestive tract, slowing carbohydrate absorption and reducing post-meal glucose spikes by 20–28%.
Does Unimate break your fast?
No. Unimate contains negligible calories and no net carbs or sugars, meaning it keeps you in a fasted state while boosting GLP-1 and satiety.
Is there a guarantee on Unicity products?
Yes, Unicity provides a 90-day money-back guarantee for all customers ordering the Feel Great System through an authorized distributor.
How fast does Unicity ship?
Orders are shipped directly from Unicity's regional warehouses and typically arrive within 2–5 business days depending on your location.
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