Unicity Science: All Clinical Studies Supporting the Feel Great System

By Fadi — Unicity Distributor & Metabolic Coach · Published 2026-06-19 · Updated 2026-06-19 · 8 min read

Quick answer: A complete guide to the clinical studies supporting Unimate and Unicity Balance. GLP-1 research, HbA1c studies, cardiovascular outcomes, gut microbiome, and...

Quick answer: The Feel Great System (Unimate + Unicity Balance) is supported by 25+ clinical and preclinical studies published through Unicity Science, including peer-reviewed research from the University of Sydney, Cleveland Clinic, and the University of Zurich. This page summarises the key findings by category.

Why Clinical Evidence Matters for a Supplement

The nutritional supplement industry is notorious for products with no scientific backing. Unicity is a significant exception. Unicity Science is the research and development arm of Unicity International, with decades of investment in clinical research. The studies referenced here range from cell studies and animal studies (mechanistic evidence) to human randomised controlled trials and observational studies (clinical evidence). Each category of evidence is noted below.

1. GLP-1 Upregulation Studies (Unimate)

Cell Study: 2.5x GLP-1 Secretion

Type: Cell study (mechanistic) | Source: Unicity Science

In intestinal L-cell models, a key microbial metabolite of Unimate — produced when gut bacteria break down chlorogenic acids — increased GLP-1 secretion by more than 2.5 times compared to control. This study established the mechanism by which Unimate stimulates GLP-1 naturally: via the gut microbiome, not via direct receptor agonism (which is how Ozempic works).

Significance: First mechanistic evidence for Unimate as a natural GLP-1 secretagogue — a compound that causes the body to produce more of its own GLP-1.

Animal Study: Elevated GLP-1 Gene Expression After 4 Weeks

Type: Animal study | Source: Unicity Science

After four weeks of daily Unimate use, subjects showed elevated GLP-1 gene expression in intestinal tissue and higher circulating GLP-1 levels in the bloodstream. This confirms that the GLP-1 effect is not just acute (immediate) but builds with sustained use — consistent with user reports of progressively better appetite control over weeks.

2. Appetite and Caloric Intake Studies (Unimate)

Human Study: 59% Fullness Increase, 11% Caloric Reduction

Type: Human crossover study | Source: Unicity Science

Overnight-fasted adults consumed either Unimate or a placebo, then rated their hunger and fullness levels over 60 minutes before eating an ad libitum meal. Results:

• Fullness increased by 59% within 15 minutes of Unimate consumption
• Caloric intake at the subsequent meal was 11% lower in the Unimate group vs placebo
• No significant adverse effects were reported

Significance: Direct human evidence that Unimate meaningfully reduces appetite and spontaneous food intake within minutes — independent of placebo effect.

3. Blood Glucose Studies (Unicity Balance)

University of Sydney: 20–28% Post-Meal Glucose Reduction

Type: Human randomised controlled trial | Source: University of Sydney (peer-reviewed)

Participants consumed one or two servings of Bios Life (the predecessor formula to Unicity Balance) before a standardised meal. Compared to placebo:

• One serving: post-meal blood glucose reduced by 20%, insulin response reduced by 13%
• Two servings: post-meal blood glucose reduced by 28%, insulin response reduced by 27%

Significance: Peer-reviewed, published human trial demonstrating dose-dependent glucose blunting. This is the study that earned Bios Life / Balance its PDR listing.

CGM Study: Lower Peak Glucose and 2-Hour Response

Type: Human observational study with continuous glucose monitoring | Source: Unicity Science

Participants wore CGM devices and took Unicity Balance 15 minutes before meals. Compared to meals without Balance, those preceded by Balance showed lower peak blood glucose and a lower overall 2-hour post-meal glucose area under the curve. The effect was consistent across both high- and low-glycaemic-index meals.

Glycemic Variability Study: 12% Reduction

Type: Human study | Source: Unicity Science

The Feel Great protocol (Unimate + Balance + 16:8 fasting) reduced glycaemic variability — the degree to which blood sugar swings up and down throughout the day — by 12% within a short observation period. Reduced glycaemic variability is independently associated with lower risk of cardiovascular disease, cognitive decline, and metabolic syndrome.

4. HbA1c and Cardiometabolic Studies (Feel Great System)

90-Day Observational Study: 38% of Pre-Diabetics Improved Risk Category

Type: 90-day observational study | Source: Unicity Science

Free-living adults used remote HbA1c testing and app-based tracking over 90 days on the Feel Great protocol. Results:

• Significant improvements in HbA1c across the full participant group
• 38% of participants who started in the pre-diabetic or diabetic range improved to a lower-risk HbA1c category
• Significant reductions in body weight and waist circumference

Significance: Real-world evidence that the Feel Great protocol, in unsupervised free-living conditions, produces clinically meaningful improvements in blood sugar control — comparable to early-stage pharmaceutical intervention.

60-Day Cardiometabolic Study

Type: 60-day interventional study | Source: Unicity Science

Results after 60 days on the Feel Great protocol:

• Significant improvements in total cholesterol and LDL cholesterol
• Significant reductions in triglycerides
• Improvements in HbA1c
• Reductions in body weight and waist circumference

Significance: The cardiometabolic risk factor improvements observed in 60 days are typically only achievable with pharmaceutical intervention (statins, metformin) or extreme dietary restriction.

5. Gut Microbiome Studies (Unicity Balance)

8-Week Prebiotic Fibre Study

Type: Human 8-week interventional study | Source: Unicity Science

After 8 weeks of taking Unicity Balance, participants showed significant increases in beneficial gut bacteria — including species known to produce short-chain fatty acids (SCFAs) that support intestinal health, immune function, and metabolic regulation. These same bacteria produce the GLP-1-stimulating metabolites that Unimate also induces — creating a positive feedback loop between the two products.

6. Weight Management and Body Composition

Preclinical: Unimate Prevents Weight Gain

Type: Preclinical (animal) study | Source: Unicity Science

In a controlled study, the Unimate group vs control showed:

• Prevention of weight gain on a standard diet
• Improved energy production in muscle tissue (mitochondrial function)
• Enhanced antioxidant levels in liver tissue

7. Wellbeing and Mood Studies

60-Day Wellbeing Study

Type: 60-day human study | Source: Unicity Science

Participants on the Feel Great protocol showed significant improvements in validated mood and wellbeing scores at both 30 and 60 days. This is consistent with the known connection between gut microbiome health (which Balance supports), GLP-1 levels (which Unimate raises), and mood regulation via the gut-brain axis.

8. Physician Reference Listing (PDR)

Both Unimate and Unicity Balance are listed in the Prescribers' Digital Reference (PDR), the database used by US physicians to reference drug information. Unicity Balance has been PDR-listed since 2002. PDR listing requires documented clinical evidence and manufacturing quality standards — it is not available to most supplement brands.

How to Access the Full Study Database

All published studies are available at unicityscience.org/studies. The database includes both published peer-reviewed research and Unicity-sponsored studies, clearly distinguished.

Order the Unicity Feel Great System

The evidence is clear. Order the Unicity Feel Great System at member pricing through this site — Unimate + Balance with personal coaching from Fadi. Or learn about the business opportunity if you want to share the Feel Great System as a Unicity distributor.

Scientific Synergy of Viscous Fiber and Fasting

The metabolic benefits of combining viscous soluble fiber (like the Biosphere Fiber matrix in Unicity Balance) with intermittent fasting are documented in clinical research. Soluble fiber slows gastric emptying and carbohydrate digestion, which stretches the satiety signal GLP-1 and keeps post-meal glucose spikes low. When you transition into the fasting window, your baseline insulin levels are already lower, allowing your body to transition into fat-burning mode (ketosis) much faster. This synergetic relationship is why combining Unimate yerba mate in the morning with Balance before lunch and dinner yields superior weight management and metabolic health outcomes compared to calorie restriction alone.

The Complex Science of Insulin Signaling and Resistance

Insulin is a hormone produced by beta cells in the pancreas, vital for regulating carbohydrates and fat metabolism. When glucose enters the blood, insulin binds to receptors on cellular membranes, initiating a cascade of intracellular signals that recruit glucose transporter proteins (GLUT4) to the cell surface. This allows glucose to enter cells, lowering blood sugar. However, chronic overconsumption of carbohydrates causes constant, high insulin release. Over time, receptors become desensitized to insulin, a condition known as insulin resistance. The pancreas compensates by producing even more insulin to force glucose into cells. This state of hyperinsulinemia prevents lipolysis (fat breakdown) and encourages lipogenesis (fat storage), particularly visceral fat accumulation around organs, leading to cardiovascular risk, metabolic syndrome, and fatigue.

The Physical Action of Soluble Fiber and Gastric Gel Barriers

Soluble fiber matrices, such as the Biosphere fiber system, operate on physical and chemical principles in the gut. Upon hydration in the stomach, the fiber particles swell and form a thick, viscous gel. This gel slows down gastric emptying, delaying the transit of food into the duodenum. In the small intestine, the viscous gel acts as a physical barrier, trapping sugars and starch molecules. This slows down their exposure to digestive enzymes (like amylase) and delays their absorption across the intestinal microvilli. Consequently, glucose enters the bloodstream gradually over several hours, rather than in a sudden spike. This flat glucose curve prevents the subsequent crash in blood sugar, eliminating reactive hypoglycemia, reducing insulin demand, and helping maintain stable, long-lasting energy.

The Metabolic Pathway of Autophagy and Ketosis

During a 16-hour fast, the body transitions from an anabolic state (storing energy) to a catabolic state (mobilizing energy). As liver glycogen stores are depleted, insulin levels drop, and glucagon levels rise. This shift activates hormone-sensitive lipase, which breaks down triglycerides in adipose tissue into free fatty acids. These fatty acids are transported to the liver, where they undergo beta-oxidation to produce ketone bodies (acetoacetate and beta-hydroxybutyrate). Ketones cross the blood-brain barrier, providing an alternative fuel source that is more energy-efficient than glucose and produces fewer reactive oxygen species. Fasting also triggers autophagy, where cells degrade damaged mitochondria, misfolded proteins, and viral components. This cellular recycling promotes longevity, reduces inflammation, and restores metabolic health.

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